Which rodenticide is considered least toxic?

Diphacinone, commonly known by the brand name Liquitox, is considered the least toxic among the listed rodenticides. It belongs to the first-generation anticoagulants, which work by disrupting the blood clotting process in rodents, leading to death. First-generation anticoagulants like diphacinone require multiple feedings over several days to be effective, which generally results in a lower risk of secondary poisoning to non-target species, including pets and wildlife.

While bromethalin, warfarin, and cholecalciferol are also used for rodent control, they each have different levels of toxicity and modes of action that can make them more hazardous. Bromethalin is highly toxic and acts as a neurotoxin, cholecalciferol (vitamin D3) can cause severe hypercalcemia and is also considered quite toxic, and warfarin, while effective, has a risk associated with potential secondary poisoning as well. Thus, diphacinone’s relatively lower toxicity profile makes it a preferable option in environments where non-target animals may be present, enhancing its safety and utility in household pest control.